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MEDICINE AT THE EDGE

FINAL SCRIPT

Narration

Mans ceaseless drive to explore…

Drives medicine to discover and pioneer new ways of curing the ills of the human body

Today medicine is at the edge ...in space,

Preparing the way for a 3 year journey to Mars,.

On Mt Everest, preventing climbing deaths on the worlds highest mountain

And underwater, treating divers for their most feared condition – the bends.

Exploring underwater beneath the sea– its a sensation often compared to floating in outer space

However, the graceful ease of a diver underwater

masks a very real physical danger.

Placed under the extreme pressure of a deep water dive, the air a diver breathes to survive turns into a threatening menace – producing nitrogen bubbles in the body - which if not properly expelled can be fatal.

Sean Gregg is a commercial deep sea diver.

18 years ago Sean left Canada to take a diving contract in American Samoa.

He set up his own commercial dive company and never went home.

Sean: It’s nice down here- the water’s 80 degrees- you do your diving in t-shirt and shorts..and it’s really nice and comfortable. The water’s warm- it’s a nice place to live.

The American Samoan capital of Pago Pago is home to the world largest tuna fishing fleet .

Tuna boats like these are in need of constant maintenance most of which has to be done underwater.

It’s Seans Gregg’s job to keep the boats clean and sea worthy .

Most of Sean’s diving takes place in 15 to 20 feet of water.

At this depth he can work quite safely for hours at a time, because his body is exposed to relatively little underwater pressure

However when Sean has to work in deeper water his job becomes far more dangerous.

Sean: Once a year we have a contract…

…with the local canneries to clean and maintain their pipeline….

…which is about 180 feet on the bottom….

…At which point your diving becomes a little more risky at that depth….

…It’s dark and it’s dirty…

…. and it’s as dangerous as you can make it.

At 180 feet, Sean breathes air at more than six times the atmospheric pressure of sea level.

His time on the bottom is very limited…

…and he has to work quickly, before the high-pressure nitrogen in his breathing air potentially risks his safety.

Nitrogen at depth makes many divers feel drunk. Known as nitrogen narcosis, it effects crucial decision-making.

Sean: It can make you disorientated when you actually don’t know what you’re doing…

. You think you’re doing something… but your movements are a lot slower and it really affects your mind and how you perform under water.

.

John Duncan is a dive medicine doctor at the Devonport Naval Hospital in Auckland NZ.

He regularly takes dive trainees down in a hyperbaric chamber to show them the effects nitrogen on behaviour.

John:The hyperbaric chamber is a pressure chamber….

or pressure vessel. It effectively lets us – to- dive people or put them under pressure without getting wet or leaving the surface.

The chamber is first taken down….

… to a depth of 60 feet.

The trainees behave quite normally..

When the divers are taken down…

… to one hundred and fifty feet the nitrogen pressure on the body’s nerves …

….increases dramatically… …

inducing a narcotic like state

Basil: Alright, fifty metres- All well?

John: At fifty meters we can see them.. they’re behaving like silly chooks…

…laughing- giggling…

…. unable to make simple sentences…

…. Nitrogen- once you’re past thirty to thirty-five meters..

…becomes just like alcohol…just like an anaesthetic

Trish: Hi my name’s Trish. I’m here because I really want a career in Hollywood.

John: If you take people deep enough it will become a general anaesthetic. The people on the Kurst…

…when it went down- air at that level would just put you straight to sleep.

Nitrogen narcosis goes away when divers return to shallower water…

…Behaviour changes instantly back to normal again.

John: Nitrogen narcosis in itself probably…

….. isn’t that dangerous to you but the effects of it- the fine motor control- so inflating a buoyancy compensator or adjusting your dive gear will become difficult. It will affect your judgement and if you’re at forty metres, or thirty-five metres, the amount of time you can spend there is very limited. Should you become disoriented and overstay your time there it affects decompression time and you may well end up running out of air.

But breathing nitrogen under pressure creates another potentially lethal condition, that deep water divers like Sean fear even more - decompression sickness, commonly known as “the bends.”

When divers dive deep, the nitrogen in the air they breathe is forced into their tissues.

If they ascend too quickly, or stay down too long this nitrogen can form bubbles…

…blocking vital blood flow to tissues and organs.

Bubbles can block blood getting to any part of the body but are especially dangerous when they form around the spine and central nervous system.

Very quickly a diver can be paralysed.

For most recreational divers these bubbles are not a problem. They’re small and get exhaled easily through the lungs.

Deep sea divers like Sean expose themselves to a life threatening hazard, because the deeper you go and the more dives you do, the more nitrogen is absorbed by the body..

John:I think commercial divers have to be very careful because they end up doing diving that a lot of us don’t do….

…. they end up diving deeper and longer. A single dive is perhaps not that dangerous…

….…. but when you’re getting repetitive diving- diving deep again day after day after day, it definitely increases the amount of nitrogen that we absorb and it increases our risk.

The only way for deep-sea divers to prevent bubbles is to decompress…

….stop regularly on the way to the surface, allowing time for any bubbles to be expelled.

It’s the same process as releasing the gas from a bottle of soda –taking the lid off gradually…

….. prevents many gas bubbles from forming.

But decompressing doesn’t always guarantee all the nitrogen bubbles will be expelled

And last year after doing ten days of 180 foot dives Sean found himself on the surface, in trouble.

Sean: I got to the surface and….

….probably within thirty seconds….

…. I looked at my partner and I said there is definitely something wrong…

…. I became very disoriented, dizziness and nausea…

…. kicked in just immediately….

….The only thing I could say to my partner…..

…. was get this gear off me and get me in the boat because there’s something wrong…

… And at that point I’d made it to the ladder ….

… of the boat and that is the last thing I remember.

Sean was now unconscious….

… an air bubble blocking blood supply to his brain.

Known as an arterial gas embolism…

…it’s a common cause of diving related deaths.

His dive partner tried to haul Sean’s180 pounds of dead weight into the boat.

He radioed for assistance but he couldn’t raise the coastguard.

Sean: He physically could not life me into the boat…

… he actually tied me off to the ladder of the boat…..

….Luckily there was a…

… local fishing boat was going out of the harbour…

….and he flagged them down and they…

….came over and they physically….

…pulled me into the dive boat…..

… and then they proceeded to go to the hospital….

…Whatever happened to me on that dive- it paralysed me from the waist down

….. It was a sort of a scary moment….

…to realise that here you are you know, you’ve been diving all your life and no problems then all of a sudden one day you do everything right but you’re now going to be in a wheelchair.

Sean regained consciousness on the way to the hospital but he had a serious case of spinal paralysis, known as “the bends”.

Worse still, there was no hyperbaric chamber on the island to treat his condition.

.

Sean:I realised that I had to get out of this place…..

…..- I would be physically done for for….

…life if I didn’t get out of this place because they had nothing to offer me…

…. so I called my wife and I said whatever you do is just get me out of this place.

Without treatment in a hyperbaric chamber Sean would be paralysed for life.

He needed to stop the nitrogen bubbles damaging his spine any further.

Sean chartered a plane to the nearest hyperbaric chamber - 2000 miles away in New Zealand.

5 days after the incident he arrived for treatment at Devonport Naval Hospital.

John:I was shocked at how bad his paraplegia was…

…. He had a dense paraplegia from the waist down affecting one leg more than the other….

…. With him being so long after injury…

… I sincerely doubted he’d walk out of here…

…. I remember saying if we could get him out of here on…

….a walker I’d be happy. I’d be ecstatic

Sean:John has seen a number of cases and he told me it was a severe case….

. I was in deep trouble…

…and – his prognosis- he didn’t know what was going to ….

…happen with this. We were going to try the treatments that he….

….was going to offer and we could only take it day by day to see what was going to happen.

Sean was sent immediately for treatment to the hyperbaric chamber

Taking Sean back to depth, breathing pure oxygen, would recompress any remaining bubbles out of his spine.

But the doctors didn’t know whether

the treatment would be too late to heal the spinal nerve damage Sean had already suffered

Sean’s initial treatment in the chamber was almost ten hours long….

…but there was no sign of movement

Sean:My first treatment- I mean, nothing changed. I …

mean I was still paralysed…. I still didn’t feel anything…

… so you look at yourself and you say- well this one doesn’t do anything for me so we’ll start again tomorrow and we’ll continue until something does change.

John: I spent a lot of time discussing with Sean the likelihood that he would not walk….

…out and due to …..

…the severity of his illness. I mean, he’s a young man married with two young children.

Sean’s 2nd treatment was his last hope.

If there was no improvement this time, the treatments would be stopped…

… there would be little the doctors could do.

For over nine hours there was again no sign of improvement.

In a final attempt to purge the bubbles and stimulate Sean nerves, the chamber was then taken down to maximum depth,150 feet.

With less than an hour remaining, Sean’s toes began to slowly twitch.

Sean:Sensations of touch and feel are still there- it’s just that your muscles…..

….are involuntarily moving which means ….

…your nerves are regenerating and causing your muscles to move…

…Your whole body is jumping- saying like- I’m going to get well, I’m going to get well

Sean continued treatment in the chamber for another 2 weeks.

Each time, more and more muscle movement returned.

He was not yet able to walk but he was determined to make a full recovery

John:He remained incredibly positive… …

…and with every new improvement …….

….he had he regained more and more improvement

After the chamber treatments,

Sean was sent to rehab. In the space of just a few weeks, he learnt to walk all over again

Sean: For me it’s like one of the greatest things in the world. Like – you know- for the rest of my life been – wheeling around in dock and watching everyone else run around when instead I’m going to walk out of here.

John: I am sure a lot of it is due to his attitude. The fact that he didn’t just lie in bed and give up….

…As far as he was concerned he was going to get better.

3 months after the incident Sean was back in business with his partner on Pago Pago harbour.

He resumed diving again…..

… even though the doctors warned him he was now even more likely

To have nitrogen problems again

Sean: It’s like falling off a horse – you climb back on it- I said…

… you know it’s not going to bother me. It’s -that accident- was something that was out of control, whatever.. We did an excessive amount of diving and it was something that just happened so you just take it more careful.

These days Sean strictly limits his deep dives and has longer decompression times in the water to make sure he’s properly expelled any nitrogen bubbles.

John: Sean had been diving again and again and again for ten days- so at the start of the next day he hadn’t cleared the nitrogen from the day before……

…And if you’re doing recurrent diving- recurrent deep diving- then you need to play it safe.

With each passing month, Sean’s spinal nerves continue to heal.

He now has close to 90% of his movement back.

Sean: The greatest decision I ever made was going to New Zealand, and having all my treatments and the rehabilitation down there…

…and I truthfully think that I would not be sitting here…

having a smile on my face and…

….be able to sort of run around a little bit…..

…and back in the diving business supporting my family

Underwater - too much air pressure can be fatal.

It’s the opposite on the highest point on earth - Mt Everest.

Here the summit is five and a half miles above sea level.

The air so thin it barely sustains life.

Ken Kamler is an high altitude physician.

He’s been a doctor on Everest six times including 1996…

… when 9 people died in a single day.

Ken: Everest is a legend.

…. It’s not just a mountain – it’s a legend. There’s a tremendous history behind it. It has a mystique …

… and in addition to being the tallest mountain in the world it’s tantalizingly close to the limit of human physiology…

…. You’re climbing in an area where physiologically your body is not able to adapt…

…. Human beings can’t adapt to an altitude above 17,000 feet…

… that’s already half the air pressure that you have at sea…

…level and the summit is one third the pressure that you have at sea level…

…so you’re climbing in a range of very much reduced oxygen pressure – your body’s not used to that. Your body’s not really equipped to deal with that and can only adapt to a very limited amount

Climbing doctors are however rare.

In most cases, its up to experienced climbers to doctor themselves.

Guy:Your body’s always under stress….

…Climbing up high…

…is sort of…

…like having a hangover and a flu at the same time. Your body can feel absolutely awful at times. But as you acclimatize you adjust to the thin atmosphere and you perform much better.

Guy Cotter guides clients up Mt Everest.

He’s climbed the mountain four times, summitting twice.

His business depends upon him…

…mastering the physical toll of high altitude mountaineering

Preparation for an attempt on Mt Everest takes many months

Yak loads of supplies and the climbers themselves….

…walk into the mountain over 10 days

This year Guy Cotter has a…

…team of fourteen going to Everest.

At Loborche, the last village before base camp

they’re reminded of the danger ahead.

…his sat’s are apparently in the nineties- but they say he’s still very wobbly and can’t stand up on his own.

Actuality – sick porter

Rachael: Ciao- how are you?

Rachael Bishop is Guy Cotter’s expedition doctor.

As the only doctor in the village she has to treat a sick

porter suffering from High Altitude Pulmonary Oedema.

HAPE is a common and often fatal illness.

The thin air at altitude has caused the porter’s lungs to collapse and leak fluid.

If left untreated …

…. the fluid will completely fill his lungs and quickly drown him

Guy: He’s on oxygen and responding well to the …

…oxygen but they’re going to put some dexmethozone into him- which will help stabilize him to move down to a lower altitude. If he stayed here he’d probably die.

Dexmethozone is an injectable….

…steroid used to lessen the effects of…

….altitude on the body

Combined with the bottled oxygen, it offers a window of relief to get the porter down to a lower altitude

Rachael: He doesn’t need a doctor, he needs someone intelligent who I can explain too how oxygen works..

The only cure for altitude illness is descent..

Recovery can be almost immediate if a patient can get to a lower altitude and thicker air in time

Rachael:People generally don’t look after their porters…

…. Because someone has taken the responsibility to bring him down and give him oxygen and drugs- he’ll probably be o.k….

…but all too many porters just get left and they die.

A few days after leaving Loborche the team arrives at Base Camp, 17500 feet above sea level.

Guy Cotter will oversee the climb from here.

His team includes his main guide Dave Hiddleston …and client Andy Hebson.

Andy:Truthfully I would like to summit- it’s- I’ve trained for two years to get ready for it. I’ve done a bunch of preliminary climbs. I’ve climbed in Latin America and in Shoyu trying to work up to this point. But I would be- as long as I put out – and it’s my best effort- whatever- as far as I get is as far as I get…But I really would love to summit this thing.

Andy’s guide Dave Hiddleston

will also be attempting to summit for the first time

An experienced high altitude guide., it’s his job to not only to help Andy up the mountain, but also be his doctor if any problems arise.

Dave:People are misunderstood about guiding in the Himalayas. We are there to give our best knowledge and medical advice and I make sure people understand that once we go into the 8000 death zone that if they do have a problem then they have to go down. If they don’t and then they do collapse- basically they’re on their own.

The extreme altitude of Mt Everest makes it impossible to climb without serious preparation.

Before a summit attempt can even be made…

…a month long acclimatisation programme has to be undertaken - climbing up and down the mountain to camps at roughly 2000 foot intervals.

The first days climb is to Camp One,1900 feet above base camp.

Only a matter hours will be spent there – just enough time for the body to begin adjusting to the thinner air.

Ken: Your body’s got to acclimatise- that’s the process that takes several weeks to be fully completed. It starts out just by breathing deeply….

…and gasping for air- that’s when people feel short of breath because they’re trying to get more oxygen. And after a while you get used to that and you begin to breath easier….

….because your body brings in other processes such as increasing the number of red blood….

….cells which carry oxygen which makes it easier for you to transport the oxygen to your tissues. Those processes take weeks

On the way to Camp One the climbers have to traverse three –story high walls of unstable ice.

But back at base camp Guy isn’t so much worried about the ice…

…as to how the climber’s bodies are holding up.

Guy:Just got a radio call from….

…David up on the ice wall- they just left an hour ago. He informs me that Andy is still feeling tired…

…He picked up a bug just a little while ago so he’s coming back down.

Andy is suffering from headaches and nausea –common complaints as climbers adjust to thin air.

Andy: Even when I left here I felt sick. I didn’t feel good when I left…

….. I was nauseated- I almost feel like I got the flu. I didn’t feel good when I left.

Rachel: There you go- one white one, one green one.

Rachael prescribes antibiotics and a few days rest at base camp –but the lack of oxygen also makes recovery slower at altitude.

Andy: Your medicine is better than David’s medicine.

He’s also picked up a stomach bug and a cough

While Andy rests at base camp, High up Mt Everest, Dave Hiddleston is making his own attempt on the summit.

He’s climbing near to what is called the Death Zone – where the oxygen content of the air is only a third of that at sea level.

Even with the assistance of bottled oxygen, getting enough of it to the body is almost impossible.

With each breathless step, the climbers slowly deteriorate.

Dave:At South Cole, 7,900 meters - stoked to be here…

…. Everything’s just so slow- choosing whether I’m gonna have tomato instant…

…noodles or continental instant noodles. Normally I’d just go - Right, I want the tomato- up there it’s like – I’ll think about it for a bit….

…Now sure what soup I wanted. Taste factors a major importance up here…

…You actually think you’re quite normal till you see yourself and realize how you’ve slowed down. I think this is why people get into so much trouble at altitude.

Summit day dawns perfectly …

but it’s the first attempt of the season…

…and the climbing ropes haven’t been properly laid.

Radio call

Dave:..we’ll try the Hillary step and see what happens. We have limited rope and limited sherpa power.

Guy: Do you think it’s worth waiting to see if anyone else behind has got some rope to try and fix.

Dave: It’s going to take us – I’m guessing three hours to reach the summit.

Making life or death climbing decisions with limited oxygen going to the brain is difficult. Guy Cotter has been there before.

He’s in constant contact with Dave, using all his high altitude experience to talk him through the climb.

Guy: Yeah that’s obviously the situation is what is is and you can’t do anything about it.

Most importantly, Guy monitors Dave’s mental state – because the lure of the summit too often leads climbers to make a fatal decision.

Ken: Twenty nine thousand foot mountain…

…and you’re 900 feet away – you want to get to the top you’ve been planning this expedition for months and you can be at the top in two hours so there is that tremendous lure to not turn around but unfortunately it has cost many people their lives.

Guy: I tell people you’ve got a tank of …

…gas and once you’ve burned up three quarters of that tank of gas you’ve got a quarter of that tank to get back…

….down and if people exceed that- if they push too hard…

…and don’t have the strength or wherewithal to get back down- they’ve kind of blown it.

Dave: South Summit….

…… believe me its hard work

Dave pushes on

At the south summit just 300 feet from the top he’s run out of rope again.

Dave: I was getting great feedback about how I was actually doing up there and I seemed to be doing fine…...

…but something was telling me – no- today’s not the day.

Guy: Pushing on at this stage if its going to take you that long to summit is pushing the envelope just a little bit too far…

… its one of those things that either on or off even though it’s a beautiful day it must be very hard for you to make this decision.

Dave: yea. We’ll start heading down now.

Ken: Everest is not the hardest mountain in the world to climb but the difference is…..

….when you’re doing that climb at 29,000 feet and you have one third as much oxygen and the temperature is thirty below zero and you’ve been out for 16 hours and you’ve had a half glass of water to drink in the past 24 hours that becomes a daunting challenge.

Dave: We may have got to the summit but I don’t know if we would have got…

….down so it’s not really worth it is it?

Back at base camp, Andy’s recovered sufficiently to climb again.

He sets off for Camp 2, 2100 feet above sea level.

It’s a long climb, made doubly difficult by extreme variations in temperature.

In the Western Cym, a large valley before Camp 2, daytime temperatures reach 40 degrees celcius.

For the climbers dressed for minus forty and struggling to breathe in the thin air, it’s a hard slog..

Andy: When I was very close to camp two I was trying to get four or five steps and I was actually seeing dots. I couldn’t even hardly breathe I felt like I had a garbage bag in my left lung.

Dave: And he just became slower and slower- to the point where we’d walk twenty feet and he’d rest for a few minutes. I think that was the moment when he started to realize what altitude climbing was all about. I mean he’s a very physical person and likes to challenge himself, when- all of a sudden- wham, he hit the wall, and he was thinking what is going on with me.

At camp 2 Andy’s collapsed - short of breath and coughing badly.

.

At this altitude it could be the first sign of pulmonary oedema or flooding of the lungs

Rachael: What’s irritating him- is he still breathing quite fast?

For Rachael, unable to physically see Andy….

…it’s a tricky diagnosis.

Rachael: How about you get the oxygen out….

….and try him on one liter for an hour with the thought that if he’s on oxygen he’ll have to breathe less fast, and if he’s breathing less quickly that might be less of an irritant for him for coughing over.

Dave: Righto so one litre an hour correct.

Rachael: Yea that’ll be good- that’ll also warm the air he’s breathing a little bit as well and that’ll be less of an irritant as well.

Andy has to spend the night on bottled oxygen. The thicker air should help him regain strength to descend the next day.

Andy: No nothing to it- piece of cake…

It was fun..

…It’s an awful long way, even if it is downhill.

Guy: Health is very important up high and if you’re unhealthy your chances of doing well at altitude are reduced severely…,

…and often a summit can be lost just through a mere cold….

…or a stomach bug.

The next day Andy decides his health isn’t good enough to continue…

his Everest dream is over.

Andy: It’s a tough mountain…

…. I don’t want to try and climb this thing unless I’m a 100% and I’ve got all the foundation laid to climb it otherwise you’re wasting your time and risking your life.

Guy: Some people never really acclimatise that well to going up really high…

… there’s no real reason for it may be he’s one of those….

….people maybe he’ s one of those people- maybe he’ll come back in a couple of years and be able to do it.

Andy: Alright here we go-See you guys- alright Guy I’ll call you tonight.

Andy: You know I’m disappointed that I didn’t summit but I’m not done yet… I’ll be back….

… All I’m gonna do right now is back up and take another run at the hill. So- that’s my plan.

The very name Mt Everest has come to mean the greatest challenge…

…but there’s another more testing environment for medicine.

Outer space and sending astronauts on a three year mission to Mars

The longest any human has survived in space is just over a year. Before any longer journeys can be attempted, space medicine has to prepare the way…answering challenges like

How to overcome the long term effect of weightlessness on the bones,

how to perform surgery onboard the spacecraft

and working out how best to select a crew to get along and work efficiently in a confined space the size of school bus.

A little over 40 years ago manned space flight was just a dream.

The science of space medicine was in its infancy…

…doing experiments to answer the question…

…could man even survive a few days in space?

Larry: The predictions about sending people into space and how they would fare were really dire before we had any experience…

- back in the mid fifties when the notion of satellites was really well known among the scientific community there were panels which looked at what was likely to happen to humans in orbit.. and the predictions were high blood pressure, excessive heart rate, nausea, dizziness inability to swallow, inability to sleep….

….When this finally happened and we sent people into space some of these symptoms occurred…

….but they occurred to the ground controllers….

….The astronauts wee fine and so largely….

…we found that short duration space flight is not really a problem other than space motion sickness.

Over forty years of manned space flight, space medicine has never lost a patient.

It’s achieved this by sending only the fittest…

…healthiest men and women into orbit, for only a short period of time.

No chances have been taken with an astronauts health before they takeoff. Prevention of health problems has been space medicine’s trump card.

Larry: Going on a space shuttle in terms of the medical threat is a bit like going on a sailboat. You carry an emergency kit, you probably have one person who is either a physician or who is trained in emergency medicine and the best you can hope to do is diagnose and stabilise… .

….Things get very different when we get out of lower earth orbit- then going home to the hospital is hardly the same and we have to have an entirely different approach to medical care for the astronauts.

Jerry: I always wanted to be an astronaut- looked up at the moon I was actually up in Canada, lying on a sand dune, looked at the moon….

…and I said- Man- our guys are up there you know I want to do that some day….

… and when I finally made it, you know it was a great moment in my life….

…and when they called me and said come on down to Johnson Space Center for training, I just- literally dropped the phone. Just jumping up and down – this is great.

One of only a handful of American astronauts who’ve spent more than a month in space…

…is former Naval physician, Jerry Linenger.

In January 1997 he took off for a stay on the Russian space station Mir.

Jerry: So as a physician, I sort of used myself as a case study if you will…..

….Psychologically mentally and psychically, so I tried to sort of peak myself out before the flight so that I could get a before and after measure if you will on how I did….

…We’re flying in looking out there and this thing is just going off in all directions- big solar panels. And you get a wow- perched above the earth; It’s just majestic….

…. Open the hatch and you get the smell of reality. Reality is sort of a musty damp down in your grandma’s cellar sort of a dirty socks smell to it- its sort of dark, electrical power margins are always right at the edge so lights are usually off and even when the lights are on they’re kind of a dim light. The feel that someone’s lived there

Linenger’s stay on Mir was to last over 5 months.

It was to be a test of both American/Russian relations and his body to withstand the stress of a long stay in space .

Jerry: I just happen to be fortunate for whatever the physiology that I have, I’m not exactly sure whatever the factor is but when I’m in space I fell good from the start. No nausea, no vomiting, no backache- no headache, as a matter of fact for five months in space I never took a medication at all.

Linengers experience on Mir isn’t normal. Most astronauts report headaches…..

…and backaches as their body fluids relocate from the legs to the chest and head, in response to their new weightless environment

Most of these effects are temporary, but only10 % of astronauts experience as smooth transition to weightlessness as Jerry Linenger.

Jerry: Space is just almost hard to imagine how effortless it is...

But that exactly how it is…. You want to fly, you take your finger you push and you’re on your way…

… Its just an incredible environment…

…All of a sudden I woke up one day and it felt like I’d lived there all my life. I was 100% spaceman….You know human beings our adaptability, our ability to change- it’s immeasurable

The human body’s remarkable ability to change however disguises a very serious health threat.

Just as astronauts begin to enjoy their new-found freedom…

… their muscles begin to rapidly shrink from lack of use.

More seriously, without the support of muscles, astronaut’s bones also loose mass, at a rate of 2% a month.

Exercise becomes vitally important to maintain remaining bone and muscle condition.

Jerry: Up in space it took everything I had to get on that treadmill every day. Painful, straps yanking into you, feels like someone sitting on your shoulders. Its as if I say…

… go for a run, put me on your back the whole way for the next hour. That’s about what it feels like. So it’s very difficult to do it. I did it religiously- again I sort of wanted to study my own body and in spite of those efforts came back with a 13% bone loss hips, lower spine, muscle strength about 65% of my pre flight strength level..so quite a bit of muscle atrophy….

…. Taught me that that environment is one great environment for floating but it’s not a very good one when you have to transition back from spaceman to earthling

At the National Rehabilitation Hospital in Washington DC, bone specialist Dr Jay Shapiro is working with paraplegics to find a solution to bone loss.

Jay: People who have sustained spinal cord injury …

… have a pattern of bone loss which is very similar to what we see in patients who are exposed to micro-gravity that is to say in the astronauts.

Dr Karyn Williams suffered a car accident 8 weeks ago. Already her bones are weakening,

so she’s taking part in a bone loss drug trial run by Dr Shapiro

Karyn: This guy is the best transfer guy in the world….

…Believe me anything that could help prevent any loss I’m all for it and I think we need to push it to make sure it happens..

…And if I’m going to be a candidate for bone loss- which I am- I want every chance I can get.

Without intervention, Dr William’s bone loss won’t level off until it reaches forty percent.

For an astronaut on a 3 year Mars mission this degree of bone loss would be devastating.

On reaching the red planet, they may even be unable to take their first step.

Jay: My feeling is the best hope for the future is to use a pharmacological agent….

….in order to cut down on the rate of bone loss. We know a lot about the use of pharmacologic agents nowadays because so many people with osteoporosis in the older age groups are treated with these agents.

Dr Shapiro is about to trial a new version of a drug used to treat osteoporosis.

It’s hoped that one 6 monthly injection will significantly reduce an astronaut’s bone loss

Jay: The first thing we’ll do is put on these goggles which …..

Another approach being worked upon to counter weightlessness, is to supply the astronauts in space with a daily dose of artificial gravity

Jay: You’re ready to take your first spin…..

Larry: We’re looking at the possibility of using…

….the smallest possible centrifuge on an intermittent…

…basis to serve as a way of overcoming the bone loss…

… muscle loss and cardiovascular problems associated with weightless ness

Dr Young sees astronauts eventually being able to exercise on the centrifuge for a couple of hours a day.

NASA plans a trial of the device on the international space station to test how much exposure to artificial gravity is necessary to maintain bone and muscle condition.

Larry: I refer to it as a spin in the gym. You go there for a work out, come back, towel off and presumably the exposure to the centrifugal force will help to keep the bones, muscles and cardiovascular…

…system from undergoing the negative effects of the adaptation of weightlessness.

Bone loss isn’t the only medical threat on a mission to Mars. Over three years, any illness or accident could occur …

…and an emergency return to earth will be impossible. The spacecraft will have to be its own ER.

Larry: Likelihood of needing some medical care if we have a crew of six that is going to be travelling for three years is greater than 50% so we will probably find in practise that the onboard physician is going to have something to do and it will be more than trivial.

In the 1960’s NASA pioneered telemedicine - monitoring astronauts vital signs and giving medical advice in space.

Now they’re working on not just advising, but treating astronauts for any condition out in space.

On the space shuttle, a remotely controlled robotic arm has long been used to repair and retrieve satellites…

…now NASA is looking to the same technology to carry out surgery in space.

In London Ontario, Dr Douglas Boyd is using a NASA funded surgical robot called Zeus to do heart bypass surgery in a way never thought possible.

Douglas: Very nice and as you move down along, you can see it going down………

….The Zeus microsurgical system consists of three components

… the surgeons console which I’m sitting at here ….

…the computer controller which

digitizes the movements I make at the controller…

…and three interactive robotic arms…

…one of which is controlled by voice activation- you can see my microphone here…I address the robot…

…Aesop..move in….

…The surgical instruments that I hold in my hands control the very fine microsurgical precise movements…

…that are performed by the small…

…graspers that go into the patients chest, which are only the size of a pencil….

…This robotic system is actually allowing surgery to be performed that up to this point was beyond human manual dexterity

Traditionally heart bypass surgery has involved splitting the patients chest open and placing them on a heart lung machine.

Using Zeus, Dr Boyd makes just two 5 mm incisions for the arms of the robot to operate

A revolutionary scalpel uses sound waves to bloodlessly cut away a good artery to replace the faulty one.

The whole operation is carried out while the patient’s heart is still beating.

The minimal impact of the robotic surgery also has important benefits for space medicine.

Douglas: Patients heal a lot faster and have substantially less pain. Patients are very comfortable after the surgery..very often they move themselves from the operating room table onto the bed

... Aesop..left….

The Zeus robot is lightweight and portable.

It was developed using aerospace technology, so that it could potentially perform lifesaving operations in space while being controlled from earth

Douglas:. Aesop..left…

…Aesop, move back move back…

…As early as a week ago we are able to manipulate this robotic system from London Ontario to Santa Barbara California which is about two thousand five hundred miles away. We’re able to very accurately manipulate this robotic arm from a very remote distance…

…Aesop- In…

…whoever had the vision of this as a tool to operate in outer…

…space was correct..I believe this is the model T of the final product that will ultimately allow us to perform operations in outer space.

Exploration beyond earth orbit will undoubtedly involve harnessing all the power of new technology…

…but the biggest barrier may ultimately be ourselves.

Jerry: I think it’s very hard to get along with two other people for five months in a school bus

. I would say the biggest surprise of my entire time in space wasn’t Halle Bop comet, it wasn’t lightning storms on the earth for thousands of miles , it was that we got along….

, and I saw people not doing well toward the end and going down a downward psychological spiral ..cut off, isolated.

On a 3 year Mars mission, astronauts would have to get along for much longer than has ever been attempted before.

Choosing the right person for the job is critical.

Jerry: I think most people think you want the most friendly person- the guy that really gets along with everybody- sort of the life of the party

but I’m not sure that the right person now that I’ve had the experience I’ve had. I think the right person is sort of the Einsteinian person

that goes into his laboratory and shuts the door and puts out the do not disturb sign, and say leave me alone, I’m really interested in what I’m doing, and they get lost in their work and their work means a lot to them.

At the end of the day that sense of satisfaction- of accomplishing some good science- getting some good work done is the thing that keeps you going.

After 5 months aboard Mir, Jerry Linenger packed his bags pleased to be heading home.

However the transition to being back on earth was not as easy as going into space.

Jerry: Earthling to spaceman- easy transition, spaceman to earthling….

…a year and a half later, I still didn’t feel exactly right when I’m out running…

…It’s a tough process – spaceman to earthling – that transition was a tough one- big surprise to me.

To regain his pre flight physical condition Jerry embarked on an extensive exercise programme – starting out in the pool.

Jerry: Tell you the water felt like mud when I first started swimming- I dove in … l

…trying to get up to the surface…

the water just felt so heavy to me being used to floating for five months..

…Actually I was amazed at how difficult it was to get back to my base line…

…and it really took about a year and a half to do that , but I think I did it the wise way by going in the water, low impact, low risk of injury, because you definitely are at risk of getting a stress fracture if you go at it too hard early on.

Three years after Mir, Jerry has a permanent 3% bone loss from his lower spine and hips. It’s a lasting legacy from his time in space, making him more vulnerable to bone fracture in old age.

Scientists will report within 5 years

on whether the human body can survive a journey to Mars.

That will be ultimate challenge for medicine at the edge

Jerry: We are space-farers, we can do it…

…and the human body can adapt- we can adapt- it’s going to be a challenge but we can do it- so just like the guys sailing in the ocean thinking they’re going to drop off the end of the earth…

…we take those risks along the way but I think we’re learning that the human being is one heck of an animal….

…and we can do things that you know- we can only dream about.

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